Tumor Anti-Angiogenesis Optimal Control Problem
The tumor anti-angiogenesis optimal control problem is stated as follows. Minimize the cost functional
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subject to the dynamic constraints

the boundary conditions

the integral constraint

and the control inequality path constraint
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The solution to the tumor anti-angiogenesis optimal control problem with tf=10000 using GPOPS-II is shown in the figures below.



GPOPS-II: Next-Generation Optimal Control Software